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KMID : 0614620040430010041
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Korean Journal of Gastroenterology
2004 Volume.43 No. 1 p.41 ~ p.46
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Cationic Trypsinogen Gene Mutation in Patients with Chronic Idiopathic Pancreatitis
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이우진/Lee WJ
김경아/이준성/전영빈/정지봉/류지곤/김용태/윤용범/김정룡/Kim KA/Lee JS/Jeon YB/Jeong JB/Ryu JK/Kim YT/Yoon YB/Kim CY
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Abstract
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Background/Aims: Mutation of Cationic trypsinogen gene is clearly associated with hereditary pancreatitis and plays an important role in the pathogenesis of pancreatitis. According to literature, this mutation is occasionally occurred in patients with pancreatitis in Western countries and Japan. The aim of this study was to find out whether the mutation was observed in Korean patients with chronic idiopathic pancreatitis.
Methods: Peripheral blood samples of 11 patients with chronic idiopathic pancreatitis were collected consecutively, and DNA was extracted from the samples. Polymerase chain reaction was performed in exon 2 and 3 of cationic trypsinogen gene. Then, DNA products were purified and sequenced.
Results: The mutation was not found in exon 2 and 3 of cationic trypsinogen gene in these patients.
Conclusions: There was no cationic trypsinogen mutation in Korean patients with chronic idiopathic pancreatitis. Further large sampled cohort study is needed
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KEYWORD
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